Promile Pure Evening Primrose Oil & Promile Marine

Many factors are responsible for the health & proper functioning of the body. The most fundamental being the nutrients obtained from the diet. The old adage "we are what we eat" is still very appropriate.

Of the many vital ingredients that go to make an balanced diet, one group, the essential fatty acids (or EFA's) is particularly important. They form part of the structure of every cell membrane and are involved in almost every biological function. They assist in giving cells elasticity, are major constituents of nerve fibre sheath and have a role in the immune response process. They are important in that they are the building blocks for a special group of hormone like substances called prostaglandins and prostacyclines that go on to control many body functions.

Essential fatty acids are polyunsaturated fats and are so called because the body cannot manufacture them and are therefore essential to the diet.

They are abundant in nature and fall into two chemical groups commonly called the Omega-3 and Omega-6 families. Omega-3 EFA's are vital to brain, heart, eye & circulation, Omega-6 EFA's are essential to all cells.

During the normal metabolism of the Omega-6 family, intermediate breakdown fatty acids are produced. One metabolite which has been the subject of much debate is gamma-linolenic acid otherwise called gamolenic acid or GLA.

Gamma-linoleic acid (GLA) is not an essential dietary component. In the normal healthy body it is manufactured from linoleic acid obtained from the diet. Why then would a supplement of GLA be of any value? The answer to this important question requires an understanding of where GLA fits into the biochemical process.

If we look at the normal metabolic process of the Omega-3 family of EFA's, at the head is the EFA called linoleic acid or LA. Enzyme action on LA by the enzyme delta-6-desaturase (d6d) produces GLA. It then undergoes further processing and can branch off to form either prostaglandin PGE1 or through to Arachidonic Acid (AA) where further splitting into cyclo-oxynase (COX) -1 or COX-2 routes can result in a build up of the pathological PGE2 series. Many factors both internal and external can influence the proper functioning of this first enzymatic phase. Internal factors like infection, disease, drugs or a lack of other essential nutrients like zinc, magnesium, vitamin B's and external factors like pollution, tobacco smoking, excess alcohol, stress can all contribute to reduce efficiency resulting in a less than adequate GLA supply. Surprisingly, there are studies which show that today's average EFA dietary intake is lower now compared with 10 years ago.

The interesting thing is, that although in normal situations GLA is produced from linoleic acid (LA) by the body, when GLA is given as a supplement we do not get the same ratio of prostaglandins as that produced when Linoleic acid is added to diet. When GLA is supplemented more PGE-1 is produced at the expense of PGE-2. The PGE-2 group is more inflammatory.

The exact basis for the findings is not fully understood, but an alteration in the resultant ratio is thought to account for the beneficial effects of GLA supplements.

A similar metabolic process occurs with the omega-3 family. Here the head EFA family is Alpha-Linoleic Acid. When this is given as a supplement there is an increase of two important fatty acids, eicosapentanoic acid (EPA) and docasapentaenoic acid (DHA). Just as the GLA to PGE-1 in the Omega-6 chain, these altered levels of fatty acids affects the eventual ratio of prostaglandins and prostacyclins, with a beneficial increase of PGE-3 series against the more inflammatory PGE-2 series.

Prostaglandins and sister products prostacyclines also play a role in reducing the stickiness of the blood, lowering bad cholesterol levels and an overall significant effect on the whole cardiovascular systems.

By balancing the diet or by diet supplements we can alter the balance of the different prostaglandin types so help to provide positive effects in many body inflammatory situations.

The role of essential fatty acids in our diet is the subject of much debate and research. The Eskimos diet and its relationship to cardiovascular disease, pollutants affecting metabolic processes and other issues have stimulated trials to increase our understanding of just where they fit into human metabolic function.

Topical questions surrounding that remain such as why do these same Eskimos (and the Japanese) have low incidence of heart disease and yet have higher than normal incidence of strokes? Why is multiple sclerosis found mainly in temperate climates and rarely in the tropics?

Research continues today to attempt to find the answers. We do seem to be on the threshold of understanding these complex reactions.

PROMILE Pure Evening Primrose Oil and PROMILE Marine have been formulated to provide the optimum balance. An increase in PGE1 and PGE3 with a decrease in the inflammatory PGE2 series.


Take Care

Our products are not intended to treat, cure or prevent any disease, nor is the information supplied in the Site intended to replace the individual advice available from your own doctor. Anyone wishing to embark on any dietary, drug, exercise or other lifestyle change intended to prevent or treat a specific disease or condition should first consult and seek clearance from a qualified health care professional. Anyone who is currently taking medicinal products and/or suffers from any form of medical disorder should consult their doctor prior to taking our products. If you have a recurring health problem that worries you, always tell your GP. If you experience an adverse reaction, stop taking our Products and seek medical advice. Food supplements should be taken in conjunction with, and not as a substitute for, a healthy lifestyle and balanced diet. The information provided on this site is for guidance only and it does not constitute medical advice.

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